Each Player assumes the role of the Earthly Representative of an Elder God, attempting to unlock four Seals, opening the Cosmic Gate, allowing that Elder God to traverse the Cosmic Void and usher in an Age of Madness upon humanity. Cthulhu: Age of Madness includes four Elder Gods, each with their own Cosmic Primal Power that is activated upon unlocking a Seal. At the start of each game, each Player chooses one Elder God Card and places it face up on the table in front of them.
The Elder God card is effectively the Players game board, the area in which "scores" are recorded.
The Cthulhu: Age of Madness core game includes the following four Elder Gods:
Additional Elder Gods will be added in Expansions to Cthulhu: Age of Madness, such as the forthcoming Age of Madness: Eternal Terrors.